|
KMID : 0363620200410040064
|
|
Journal of Korean Oriental Medicine
2020 Volume.41 No. 4 p.64 ~ p.71
|
|
|
Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation
|
|
Han Chang-Woo
|
|
|
Abstract
|
|
|
Objectives: This study was done to look into whether Nrf2 take some role in the anti-lipogenic effect of kaurenoic acid in a nonalcoholic fatty liver disease (NAFLD) cellular model.
Materials and Methods: We measured the effect of kaurenoic acid on intracellular steatosis and Nrf2 activation. Next, the effect of kaurenoic acid on SREBP-1c and some lipogenic genes in palmitate treated HepG2 cells with or without Nrf2 silencing.
Results: The increased SREBP-1c expression was significantly decreased by concomitant kaurenoic acid treatment in non-targeting negative control siRNA transfected HepG2 cells. However, kaurenoic acid did not significantly inhibited increased SREBP-1c level in Nrf2 specific siRNA transfected HepG2 cells
Conclusions: Kaurenoic acid has a potential to activate Nrf2, which may suppress SREBP-1c mediated intracellular steatosis in HepG2 cells.
|
|
|
KEYWORD
|
|
|
kaurenoic acid, non-alcoholic fatty liver disease, Nrf2
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|